New Urine Test Shows High Confidence in Correctly Diagnosing IC

Researchers around the world have pursued the holy grail of diagnostic testing for IC/BPS – a simple, non-invasive urine test. Researchers at Beaumont Hospital, the nations leading IC research center, have developed a urine test which corrects classified all Hunner’s lesion patients. Simply astonishing!

In the IP4IC study, researchers measured urinary cytokine levels in 146 IC patients and 262 asymptomatic controls. A separate smaller dataset, P3, was collected in the clinic with physician documented diagnosis.

This method correctly classified 146 of 146 (100%) IC participants, both with and without Hunner’s lesions, and 262 of 262 (100%) control participants in the training set. For the validation set, 100% (N=26/26) IC patients and 96.3% (N=26/27) controls were correctly identified. A combination of both non-invasive urinary cytokines as well as pain and symptom scores was required for a classifier with strong validity. This may be the holy grail of new diagnostic testing for IC. It is high confidence urine test that could drive a personalized medical diagnosis of patients with suspicion of IC based on inflammation and pain and symptoms.

Source: Lamb L, et al. MP39-11 TOWARD PERSONALIZED MEDICINE FOR AN INTERSTITIAL CYSTITIS INDIVIDUALIZED DIAGNOSIS USING A NEW BLADDER INFLAMMATION SCORE – AUA 2018 Annual Meeting Poster Session

By Jill Osborne|2018-08-27T15:23:52-07:00August 17th, 2018|Research|Comments Off

About the Author: Jill Osborne

My Google Profile+ Jill Heidi Osborne is the president and founder of the Interstitial Cystitis Network, a health education company dedicated to interstitial cystitis, bladder pain syndrome and other pelvic pain disorders. As the editor and lead author of the ICN and the IC Optimist magazine, Jill is proud of the academic recognition that her website has achieved. The University of London rated the ICN as the top IC website for accuracy, credibility, readability and quality. (Int Urogynecol J - April 2013). Harvard Medical School rated both Medscape and the ICN as the top two websites dedicated to IC. (Urology - Sept 11). For many years, Jill served on the Congressionally Directed Medical Research Panel (US Army) where she collaborated with researchers to evaluate new IC research studies for possible funding. Jill has conducted and/or collaborates on a variety of IC research studies on new therapeutics, pain care, sexuality, the use of medical marijuana, menopause and the cost of treatments, shining a light on issues that influence patient quality of life. An IC support group leader and national spokesperson for the past 20 years, she has represented the IC community on radio, TV shows, at medical conferences. She has written hundreds of articles on IC and its related conditions. Jill has a Bachelors Degree in Pharmacology and a Masters in Psychology, Jill was named Presidential Management Intern (aka Fellowship) while in graduate school. (She was unable to earn her PhD due to the onset of her IC.) She spends the majority of her time providing WELLNESS COACHING for patients in need and developing new, internet based educational and support tools for IC patients, including new live IC Support Group Meetings via Youtube and the “Living with IC” video series. Jill was diagnosed with IC at the age of 32 but first showed symptoms at the age of 12.