Platelet-rich plasma therapy uses a patients own blood cells and growth factors to improve and increase healing in the bladder. This treatment requires a blood sample from the patient which is then processed to separate the platelets from other components of blood. This solution is then injected into the bladder wall. The risk of side effects is considered low because this treatment is derived from a patients own cells. Two new publications show that it appears to help restore the structural integrity and healing of the bladder wall in patients with interstitial cystitis and/or bladder pain syndrome.
Platelet-rich Plasma Structurally Improves The Bladder Wall
This study from China sought to determine if Platelet Rich Plasma improved the structural integrity of the bladder wall, specifically iurothelial cell growth, cytoskeleton, inflammation, and barrier function protein expressions in patients with IC/BPS. 19 patients with IC/BPS underwent 4 monthly intravesical PRP injections. Bladder biopsies were taken at the first and fourth PRP treatment. After PRP injections, the functional bladder capacity and maximum flow rate increased, and the visual analog scale (VAS) of pain, IC symptom index, IC problem index, O’Leary-Sant symptom score, and GRA improved in all patients. The level of urothelial barrier function protein and cell proliferation protein expression in the patients with IC/BPS was increased after repeat intravesical PRP injections. Intravesical repeat PRP injections may have potential to improve urothelial health and result in symptoms improvement in the patients with IC/BPS.
Source: Jhang J, et al. IMPROVED UROTHELIAL CELL PROLIFERATION, CYTOSKELETON AND BARRIER FUNCTION PROTEIN EXPRESSION IN THE PATIENTS WITH INTERSTITIAL CYSTITIS/BLADDER PAIN SYNDROME AFTER INTRAVESICAL PLATELET-RICH PLASMA INJECTION. Neurourol J. 2022 Jan 20
Does Platelet-rich Plasma Help Bladder Healing?
Researchers in Italy reviewed the efficacy of intravesical Platelet Rich Plasma injections in subjects with IC/BPS. Treatment with PRP appears to show less bleeding, fewer inflammatory cytokines and an increase in the healthy division of urothelial cells in animal testing. In the three clinical trials reviewed, patients who underwent monthly PRP injections were found to have a statistically significant improvement in symptoms with modulation of growth factors and inflammatory proteins. This suggests that this treatment could improve urothelial regeneration and reduce chronic inflammation.
Spirce: Trama F, et al. USE OF INTRAVESICAL INJECTIONS OF PLATELET-RICH PLASMA FOR THE TREATMENT OF BLADDER PAIN SYNDROME: A COMPREHENSIVE LITERATURE REVIEW. Antibiotics (Basel). 2021 Oct 1;10(10):1194