Natural, OTC Supplements Suggested For Bladder Health

In 2011, the leading urology association in the world, the American Urological Association (, published their first Guidelines for the Diagnosis and Treatment of IC/BPS. Using a six step treatment protocol, they encouraged patients to start with Step One (self-help strategies, diet modification and OTC nutraceuticals) BEFORE proceeding to Step Two, Three, Four and so forth. Why? Self-help strategies have few side effects, are far more affordable and are well known to improve bladder symptoms and quality of life. In the IC and pelvic pain courses offered at the national AUA conference, several supplements are often recommended to physicians to discuss and/or share with their patients.

Key Ingredients to Look For

  • Palmitoylethanolamide (PEA) – Pain reducing effect in  IC patients. Found in Bladder Builder, PEAORA & AloePath.
  • Chondroitin Sulfate – Bladder coating effect. One study released in 2020 found that chondroitin was the most effective at restoring the superficial integrity of the bladder wall. Chondroitin has been used in bladder instillations for years, in both UraCyst® and IaLuril®. Found in Bladder Builder, Bladder RestCystoprotek, CystoMend & Cysto Renew
  • Sodium Hyaluronate – Bladder coating effect. Hyaluronate has also bee used for years in bladder instillations, in both Cystistat® and IaLuril®. Found in CystoProtek.
  • Quercetin – Is believed to have an antihistaminic effect and has been used in almost every urinary supplement produced in the past two decades. Avoid “citrus” bioflavonoids. Look for bioflavonoids derived from the saphora plant. Found in Bladder Builder, Bladder Rest, CystoMend, CystoProtek, Cysto Renew
  • Aloe – has a calming and soothing effect to the urinary tract though some patients may be sensitive. Must be anthraquinone free. Found in AloePath, Cysto Renew.

Urinary Tract Comfort, Irritation, Frequency, Urgency

ALOEPATH® combines organic aloe, calcium, magnesium and PEA for a soothing and calming effect.* A more comprehensive formula than Desert Harvest Aloe. Anthroquinone free. Learn more here! 

BLADDER REST® for a protective (chondroitin) and antihistaminic (quercetin) effect. This is a precise formula for those who struggle with sensitivities. Learn more here! 

BLADDER BUILDER® is a more complex formula that offers a protective effect (chondroitin), antihistaminic (quercetin), pain support (PEA),  collagen, probiotics and various amino acids. Learn more here!

CystoMend® is similar to CystoProtek but with the addition of pumpkin seed extra for its anti-inflammatory effect.

CystoProtek® is an older, but well loved formula that combines protective (chondroitin) and antihistaminic (quercetin) effects. It does, unfortunately, use shellfish and pork for those who are intolerant, etc. Learn more here! 

Cysto Renew® combines chondroitin, quercetin and aloe.* Learn more here! 
(*Some are intolerant to aloe products, causing stomach and gut distress.)

For Chronic UTI Prevention:

PRVNT® (compare with Ellura®) utilizes PAC’s and D-Mannose to reduce the risk of infection. Learn more here!

My Daily D-Mannose may help prevent E. coli bacterial infection of the bladder by helping to flush bacteria from the urinary tract.

For Pain Suppression:

PEAORA® combines palmitoylethanlamide with resveratrol to reduce pain and discomfort. A research study released in 2019 demonstrated that this combination was remarkably successful at reducing pain in IC patients. Learn more here! 

For Vitamin and Mineral Supplementation:

BLADDER SMART® Low Acid MultiVitamin is ideal for anyone who in need of a vitamin and mineral complex without the acid irritation found in traditional supplements.  Learn more here!

We also carry several other individual vitamins from Nature’s Path including Vitamin B12, D3, Ester C, etc. Learn more here!

For Diet Sensitivity:

Prelief® reduces the acid in foods that you may be eating, such as coffee, citrus, soda, etc. Learn more here! 

 Frequently Asked Questions

Why does the ICN offer supplements?

The ICN only sold educational materials (books, videos, etc.) for years before it came to our attention that some doctors were promoting the use of a medical device (and surgery) as a first line therapy for IC. In fact, some patients weren’t even told about oral medications in favor of the more profitable surgical techniques. We were outraged. We believed that patients should be educated about the many treatment options available, including traditional and alternative therapies. Thankfully, the AUA not only agreed with our approach but implemented the same philosophy in their treatment guidelines.

How does the ICN select supplements?

We look first at the company selling the product and their focus on quality. We ask why the product was developed.  Are the ingredients known to help bladder symptoms? Is the pricing fair and affordable? We believe that the supplements that we carry today are the best on the market.

Do all doctors recommend the use of supplements?

With the AUA’s recommendation of neutraceuticals in their guidelines, far more physicians are comfortable suggesting OTC products. Almost every class on IC or pelvic pain at the AUA Annual meeting offers comprehensive discussions of available OTC supplements. Unfortunately, doctors who don’t attend the conferences or have not read the guidelines simply may not know that they exist. If your doctor is unaware of the AUA guidelines, you can print out a copy from our website which shares their position on supplement use.

Which one should you select?

Given the fact that IC patients often have very unique food sensitivities, begin first by reviewing the supplement ingredients on our website. If you are sensitive to any of the ingredients, then move to a different supplement.  Ultimately, though