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Handbook > Quercetin
A hot term in 2001-2 was bioflavonoids. Bioflavonoids are found in plants, especially onions, spices, green tea, and red wine. They have anti-oxidant properties, both as free radical scavengers and as inhibitors of xanthine oxidase. They also have anti-inflammatory properties, blocking both chemokines and cytokines and they interfere with tyrosine kinase enzyme activation, inhibiting the division and growth of T cells. Interestingly for IC, some bioflavonoids have been shown to block mast cell activity. Finally, they have antimicrobial and anti-fungal properties.
Quercetin was first used effectively with
prostatitis patients. In a recent study of men with nonbacterial prostatitis,
67% of patients taking a purified quercetin 500 mg capsule twice a day
had a significant improvement in symptoms (at least 25% improvement in
symptom score) versus 20% of the men taking placebo. Using a quercetin
formulation that includes bromelain and papain to enhance quercetin absorption
(Prosta-Q) 82% of the men had a significant
improvement in symptoms [Quercetin in Men with Category III Chronic
Prostatitis: A Preliminary Prospective, Double Blinded, Placebo Controlled
Trial Shoskes DA, Zeitlin I, Shahed A, Rajfer J. Urology, 54(6):960-963,
Because prostatitis and interstitial cystitis are quite similar, researchers wondered if it could also help interstitial cystitis. Dan Shoskes, MD, currently at the Cleveland Clinic of Florida, has conducted several studies that demonstrate that quercetin can be very effective in reducing the symptoms of IC. He has also spoken of his research in the ICN Guest Lectures. Review the transcript here!
Dan Shoskes reported that the treatment was "well tolerated and provided significant symptomatic improvement in patients with IC." He said "The only theoretical risk is the combination of Cysta-Q with the quinolone antibiotics (Cipro, Levaquin, Floxin, Tequin). Cysta-Q may prevent these antibiotics from binding properly to bacteria. The other concern is for pregnant women. It is known that antioxidants like quercetin at very high doses can actually begin to function as pro-oxidants and cause tissue damage. A Japanese study has shown that levels of quercetin in newborns are several times higher than in their mothers. Therefore, the use of Cysta-Q during pregnancy should be avoided."
In addition to the CystaQ & ProstaQ line of products, a new line of food supplements were introduced by Dr. Theoharis Theoharides and colleagues. The Algonot family of products (Algonot, Cystoprotek & Prostoprotek) have created a lot of excitement among ICN users. They not only use quercetin, but also include glucosamine, chrondroitin and sodium hyaluronate. These latter ingredients are believed to help restore or rebuild the bladder wall.
In a lecture by Dr. Theoharides on our website, he offered:
The ICN follows the HonCode: Health Code of Conduct for Medical Web
Sites. As such, we do not and cannot recommend any books or materials
which offer herbal strategies, yet offer no research supporting those
The ICN follows the HonCode: Health Code of Conduct for Medical Web Sites. As such, we do not and cannot recommend any books or materials which offer herbal strategies, yet offer no research supporting those claims