Come To Chat Room - Interstitial Cystitis Network Support Forum

**Kathi** · 07-26-2005, 11:49 AM

edythe · 08-01-2005, 02:22 PM

Could any of you tell me if you get flare-ups when using Diflucan, or other fungals....not just the cremes (as they contain propylene glycol, and oxalic acid, so a flare is understandable but specifically from the pill (oral ) form. Really important on some research on autistic kids, as they use the oral form. Thank you for your help.

***Katrina*** · 08-02-2005, 08:03 AM

My IC never had any difficulty with Diflucan that I could tell...but my stomach...it was happier without it. I don't know of many ICers ever having problems with oral yeast treatment. There are a few exceptions ....those that are sensitive to many meds...

edythe · 08-02-2005, 08:25 AM

Thank you for your reply...I think from some research I am doing on children, and what I have read from members of the VP Foundation, and in some of the literature on IC and studies they have done...that the people reacting to anti-fungals are those that react to oxalates. These antifungals have propylene glycol (and glycols are precusors to oxalates, plus the medication itself had oxalic acid in it._ So for a pain sufferer with damaged tissues, who has the tendency to react to oxalates these oxalates break down the tissue even more)
The group in the IC area that is reacting, while I don't know what %, is probably the group with kidney stones in their family.
IC reasearchers from what I have read know about this as asking about kidney stones in the family is one of the questions noted in the diagnosis in "the Interstitial Cystitus Survival Guide" this oxalate issue is why they ask....if you have the genetic disposition to react to high oxalate exposure, and you have the damaged membranes you have a double whammy producing pain...and for that subset...everytime they have exposure to high oxalate foods , or under stress when the body produces them, they are going to have more pain, and have even more tissue breakdwon.
I see the signs of it all over the postings on some of the food these people react to, or the meds they are on. It makes me really sad, because I know in this subset of people if they looked into the oxalate issue and educated themselves they would get relief. I don't know how (am not to computer savy) how to get this from a private email onto your site but if you know how, perhaps you can post it so others can read it.
Obviously this oxalate issue is not going to affect everyone....BUT...one has to remember that oxalates do do cause problems in healthy tissues ONLY damaged ones. And this is found in other parts of the body...oxalates have been studied for years in their connection to colitis, irritable bowel etc.
The damage done by oxalates does not just affect the uro-genital area...but moves to other parts of the body.
For any one who would like to learn more about what we are putting together, the research and I will have a website up on this low oxalate issue/diet where people can understand it. We would welcome some of you already more IC savy people to share info with us, as some of the protocls you people use can be of help to us.
Plus some of the biochemical dysfunctions we will discuss may be of interest to your group....and we can all help each other. There are areas that perhaps you can bring back to your IC researchers which they may want to take a closer look at in their research such as sulfur methylation pathways, cysteine, thiols etc.
Thanks again for your response. As I said it may not help everyone, but those particularly with kidney stones in their family may be prone to this...or family histories of bowel disorders.

***Katrina*** · 08-03-2005, 05:46 AM

Thanks for sharing that....one of the reasons I gave up taking it was because of what it was doing to my digestive system...huge problems all throughout! I still keep it around for the yeast infections that won't go away....and I never noticed it directly hurting my IC...but it has caused me problems elsewhere!