Latest Blog Article: Interstitial Cystitis Treatment Guidelines Updated by AUA in Fall 2014
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  1. #1
    ICN Member
    Join Date
    Jan 2010
    Posts
    16

    Amitriptyline (aka Elavil) not working anymore! Why, what do I do???

    I started Amitriptyline about 2 months ago. Overnight it significantly reduced my pain (mine is urethral), and literally gave me my life back. However, a couple weeks back it stopped working...I'm pretty devastated and don't know what to do. To finally be able to live my life again, and then to have it all taken away again has been pretty crushing. Has anyone else experienced this? Is it maybe that my body has developed a tolerance for it? Would upping my dosage help? I am currently on 25mg once a day before bed. Any advice/thoughts would be greatly appreciated.

    Thanks!

  2. #2
    ICN Member
    Join Date
    Apr 2010
    Location
    Washington State
    Posts
    106
    I've read that people can develop a tolerance and have to continue to increase the dosage. I would talk to your doctor about increasing it if the side effects don't bother you.

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