Two bladder instills work well in combination! Hyaluronate and Chondroitin!

[icnmgrjill]

What makes this study particularly interesting is that for ten years or longer the two companies that made HA and CS competed with each other in clinical trials... thus it's quite ironic that after years of animosity, the two medications actually work very well together in helping to regenerate the bladder lining. Check out this study from Italy! Fascinating! - Jill

Impact of intravesical hyaluronic acid and chondroitin sulfate on bladder pain syndrome/interstitial cystitis - Abstract

Mon, 03 October 2011

Urology Department, IRCCS Policlinico San Matteo, Pavia, Italy.

Intravesical instillations of hyaluronic acid (HA) and chondroitin sulfate (CS) may lead to regeneration of the damaged glycosaminoglycan layer in interstitial cystitis/bladder pain syndrome (IC/BPS).

Twenty-two patients with IC/BPS received intravesical instillations (40 ml) of sodium HA 1.6% and CS 2.0% in 0.9% saline solution (IALURIL®, IBSA) once weekly for 8 weeks, then once every 2 weeks for the next 6 months.
The score for urgency was reduced from 6.5 to 3.6 (p = 0.0001), with a reduction in pain scores from an average of 5.6 to 3.2 (p = 0.0001). The average urine volume increased from 129.7 to 162 ml (p < 0.0001), with a reduction in the number of voids in 24 h, from 14 to 11.6 (p < 0.0001). The IC Symptom and Problem Index decreased from 25.7 to 20.3 (p < 0.0001), and the Pain Urgency Frequency score, from 18.7 to 12.8 (p < 0.0001).
The treatment appeared to be effective and well tolerated in IC/BPS in this initial experience.

Written by:
Porru D, Leva F, Parmigiani A, Barletta D, Choussos D, Gardella B, Daccò MD, Nappi RE, Allegri M, Tinelli C, Bianchi CM, Spinillo A, Rovereto B. Are you the author?

Reference: Int Urogynecol J. 2011 Sep 9. Epub ahead of print.
doi: 10.1007/s00192-011-1546-5

[Landish]

It's a good news but how long we have to wait for the bureaucracy and approval from the FDA ? How many years people have to suffer to try a new medication. You can find hyaluronic acid and chondroitin sulfate in capsules over the counter but you cannot buy instills. It's just so illogical.

[polygon]

This sounds great, I wonder if it would work as efficiently doing the instills one at a time, or if the effects are only noticeable when instilling them together.
Either way, glad to hear!

[Bodicea]

In cosmo(magazine) they have an article about a woman who had severe vaginal pain. Anyway she had Botox and it helped her wonderfully. Since then I really am thinking how great it would be. Does anyone know when it will be approved?

Laura

[Wallander]

I have this instill (Ialuril), but so far my frequency has gone up significantly as well as my pain urgency frequency.

I hope that I'll be able to write: it did finally work for me somewhere in Dec. or Jan. and that I'm simply a 'slow patient' and not one of the exceptions where it doesn't work.

[Julie B]

Jill, I love your comment at the beginning....isn't that the story of the IC community? Come on, people play NICE!

This reminds me of the phrase from the F.I.R.S.T. Robotics organization (www.usfirst.org if you are interested....)

They call it "Co-opertition" Basically, enjoy the competition....but still cooperate!

It isn't about greediness, about fame to be published in journals, or about being the keynote speaker at a conference...........

IT IS ABOUT THE PATIENT!

Just had to say that...................... ::grins::

[DeannaM]

I tried Botox about 6 years ago for my IC. It worked wonderfully for the urgency and frequency, but my pain increased greatly. I ended up with pelvic adhesions, both my OB and Uro think it was triggered by the botox.

[LyseMagness]

Has anyone tried oral use of the hyalluronic acid and chondroitin sulfate to see if any benefit might be derived from that. I realize that this would be a completely different and diluted way of getting these chemicals into the bladder, but it seems it might be worth trying until the FDA gets around to okaying instillation here in the United States.

[Barbm]

I have also been reading about the installs with glucosamine chondroitin. These are both in Cystoprotek. It is interesting that both of these drugs are well absorbed and both are excreted in the urine. What this means is that you should be able to get the same effects from this over the counter oral supplement as you do from a bladder instill. There are two observational studies that show Cystoprotek works well. Unfortunately,there are no double- blind placebo controlled trials with this supplement.

[bjcov]

Barb, I'm trying to figure out if I should buy Cystoprotek or aloe. Which would you prefer?

[Barbm]

I would definitely go with the Cystoprotek. I have not found any medical literature supporting aloe Vera.

[lonen86]

Im on Uracyst instilations and I love it . My pain , urgency and frequency went down significantly . I believe that without it I would be suffering , my quality of life is better because of Uracyst . Uracyst is made in Canada and shipped to 58 countries around the world . The company told me that is doing clinical trials and will be approved in the US is a couple of years , is made in my home town . It has been approved in Europe for a few years now and in Spain is included in their health care .

[bjcov]

I would love to see if Uracyst would work for me! 2 yrs is ridiculous! Not fair!

[purpleviolet]

Why is our country so behind these other countries. Hasn't this instill been out there for years (Uracyst)? How come Canadians can get it?

[icnmgrjill]

Because it hasn't performed well in research studies here in the USA... not much better than placebo if I remember correctly.

[bjcov]

Thanks Jill. I didn't know that. I have heard great things about uracyst. But I'm glad that at least some people get benefit from it!