Interesting discovery about Wellburtrin, urethra spam, and xanax

[mom_in_ma]

I post a couple of days ago about antidepressants that don't cause retention. Since then, I'm learning a lot!

I can't take SSRIs - Paxil, Prozac, etc. because they are serotonin inhibitors and cause the bladder to relax too much. Combined with PFD and for me you have retention and PAIN. But, they help so much with my brain.

So, my doctor suggested we try am SNRIs (norepinephrine inhibitors) - I've been on wellbutrin (a baby dose) since Friday afternoon. Most of the side effects are going away, but I noticed today that my bladder pain increases significantly within an hour of taking a dose.

Always always curious, I figured out how they work this afternoon and discovered THIS - norepinephrine causes urethral smooth muscle to contract! While the bladder is fine, the urethra is pulled tight and shut and again...retention.

So, dammed if I do and dammed if I don't....MAYBE.

I've also discovered that if I take a small dose of xanax about 1.2 hour when I start to feel the spasms, I feel fine within about fifteen minutes. It stops the spasms.

I'm hoping...maybe...possibly...PLEASE?????....that these are part of what my doctor calls activation symptoms (as were the headaches and feelings of drinking a pot of coffee) and that after my brain gets used to the increase in norepinephrine the spasms will subside. Crossing fingers.

[icnewlywed]

What about amitripalene (sp?) ? I take it actually for my ic and not my horrible anxiety (thankfully I can tolerate paxil). However, I have noticed a change in my mood since starting amitripalyne with my paxil.

I LOVE xanax. I could not cope with IC if it was not for my .25 mg xanax pill. I take one with pyridium whenver I feel a flare coming on and more times than not it does the trick.

Good luck in your medication search. Finding the right cocktail of meds can be tough!

[snowgirl]

I post a couple of days ago about antidepressants that don't cause retention. Since then, I'm learning a lot!

I can't take SSRIs - Paxil, Prozac, etc. because they are serotonin inhibitors and cause the bladder to relax too much. Combined with PFD and for me you have retention and PAIN. But, they help so much with my brain.

So, my doctor suggested we try am SNRIs (norepinephrine inhibitors) - I've been on wellbutrin (a baby dose) since Friday afternoon. Most of the side effects are going away, but I noticed today that my bladder pain increases significantly within an hour of taking a dose.

Always always curious, I figured out how they work this afternoon and discovered THIS - norepinephrine causes urethral smooth muscle to contract! While the bladder is fine, the urethra is pulled tight and shut and again...retention.

So, dammed if I do and dammed if I don't....MAYBE.

I've also discovered that if I take a small dose of xanax about 1.2 hour when I start to feel the spasms, I feel fine within about fifteen minutes. It stops the spasms.

I'm hoping...maybe...possibly...PLEASE?????....that these are part of what my doctor calls activation symptoms (as were the headaches and feelings of drinking a pot of coffee) and that after my brain gets used to the increase in norepinephrine the spasms will subside. Crossing fingers.

I cant take ANY anti depressans my pscy md has thrown in the towel. All gave me bladder retention. It is the norepinephrine that is suppose to help with pain however my NPractioner friend told me the Norepinephrine is what will give you the retention. In my case she was right cymbalta and nortriplline both. I even tried mood stabilizers nope same thing. I am in high dose of vitamin d and fish oil that it is/ Guess I will quit the pcy md pay him for what xanax my family md can do that> Vicky