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10-30-2006, 02:24 PM
UroToday.com - Several promising markers, led by antiproliferative factor and heparin binding epidermal growth factor-like growth factor may eventually be useful in diagnosing interstitial cystitis. Lokeshwar and colleagues at the University of Miami recently showed that urinary urinate and sulfated glycosaminoglycans (GAG) levels correlate with IC severity, measured using the O'Leary-Sant questionnaire. Sensitivity was 80% ad specificity 92% to detect patients with IC with severe symptoms. In a new study, they examined the profile of urinary glycosaminoglycans species in patients with IC, and examined a correlation between urinary GAG profile and IC severity. They also looked at severity as it correlates with urinary hyaluronic acid levels.
Urine specimens and completed O'Leary-Sant interstitial cystitis symptom and problem indexes (ICSI and ICPI) were obtained from 29 patients with IC, 14 normals, and 14 patients with other benign pelvic and bladder conditions. Eight IC patients and 4 normals were followed over the next 12 months. Urinary glycosaminoglycans profile was determined by gel filtration chromatography. Glycosaminoglycan peaks were analyzed by polyacrylamide gel electrophoresis.
The authors found that in patients with severe IC symptoms, urine specimens contained 3 uronate peaks. Only 1 or 2 peaks were found in the other groups. Urinary hyaluronic acid levels were 3 to 4 fold higher in patients with severe IC symptoms than in the other groups. Glycosaminoglycan profile and hyaluronic acid levels detected IC severity with 83% sensitivity and 89.7% and 74.4% specificity respectively. In the short term and long term studies, glycosaminoglycans profile and hyaluronic acid levels significantly correlated with IC severity.
While there are easier ways to monitor severity (like a questionnaire), the authors findings may present another valuable clue as to pathogenesis and potential treatment of this disorder.
By Philip M Hanno MD, MPH
J. Urol, Volume 176, Issue 3, Pages 1001-1007 (September 2006)
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Urine specimens and completed O'Leary-Sant interstitial cystitis symptom and problem indexes (ICSI and ICPI) were obtained from 29 patients with IC, 14 normals, and 14 patients with other benign pelvic and bladder conditions. Eight IC patients and 4 normals were followed over the next 12 months. Urinary glycosaminoglycans profile was determined by gel filtration chromatography. Glycosaminoglycan peaks were analyzed by polyacrylamide gel electrophoresis.
The authors found that in patients with severe IC symptoms, urine specimens contained 3 uronate peaks. Only 1 or 2 peaks were found in the other groups. Urinary hyaluronic acid levels were 3 to 4 fold higher in patients with severe IC symptoms than in the other groups. Glycosaminoglycan profile and hyaluronic acid levels detected IC severity with 83% sensitivity and 89.7% and 74.4% specificity respectively. In the short term and long term studies, glycosaminoglycans profile and hyaluronic acid levels significantly correlated with IC severity.
While there are easier ways to monitor severity (like a questionnaire), the authors findings may present another valuable clue as to pathogenesis and potential treatment of this disorder.
By Philip M Hanno MD, MPH
J. Urol, Volume 176, Issue 3, Pages 1001-1007 (September 2006)
Link Here.
UroToday - the only urology website with original content written by global urology key opinion leaders actively engaged in clinical practice.
To access the latest urology news releases from UroToday, go to:
www.urotoday.com
Copyright © 2006 - UroToday
< back to top