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EGF And HB-EGF Modulate Inward Potassium Current In Human Bladder Urothelial Cells From Normal And Interstitial Cystitis Patients
Main Category: Urology / Nephrology News
Article Date: 16 Oct 2006 - 0:00am (PDT)
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UroToday.com - There are currently two well-known bladder hypersensory syndromes - overactive bladder (OAB) and interstitial cystitis (BPS/IC). Because BPS/IC is associated with chronic bladder pain, it represents potentially a more challenging clinical problem. There are no treatments that target specifically the bladder sensory pathways.
Recent data suggest that bladder urothelial cells do more than provide a barrier function, but also may initiate bladder sensory signals. They can release putative neurotransmitters including ATP and nitric oxide in response to stretch or pharmacologic stimuli. They also express receptors typically found on neurons. Skin epithelial cells can function as sensors, and it may be that bladder urothelial cells function this way as well.
To better understand the potential for the bladder urothelial cell to participate in bladder sensory signaling, Yan Sun and colleagues from the University of Maryland designed single cell electrophysiological experiments in human normal and BPS/IC bladder urothelial cells. An inward rectifying potassium current was detected in all cells. A decreased conductance was detected in BPS/IC bladder urothelial cells. Conversely, increased potassium conductivity was induced in BPS/IC bladder urothelial cells by exposure to heparin binding epidermal growth factor-like growth factor (HB-EGF). The electrophysiological phenotype of normal and BPS/IC bladder urothelial cells was switched by exposing them to epidermal growth factor and genistein as well as HB-EGF.
The authors believe their findings suggest that potassium currents caused by alterations in growth factor levels could play a role in the pathophysiology of bladder urothelial cells in BPS/IC patients, yielding a potential future target for therapeutic intervention.
By Philip Hanno, MD, MPH
Am J Physiol Cell Physiol (July 12, 2006).
doi:10.1152/ajpcell.00209.2006
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20th October 2006
home newsletter advertise accessibility contact
Photo of medical professional
Archive Search
advanced searches >>
Medical Abbreviations
www.medilexicon.com
Urology / Nephrology News
Useful Links
EGF And HB-EGF Modulate Inward Potassium Current In Human Bladder Urothelial Cells From Normal And Interstitial Cystitis Patients
Main Category: Urology / Nephrology News
Article Date: 16 Oct 2006 - 0:00am (PDT)
| email this article | printer friendly | view or write opinions |
sign up to our weekly newsletter Sign up for news alerts
UroToday.com - There are currently two well-known bladder hypersensory syndromes - overactive bladder (OAB) and interstitial cystitis (BPS/IC). Because BPS/IC is associated with chronic bladder pain, it represents potentially a more challenging clinical problem. There are no treatments that target specifically the bladder sensory pathways.
Recent data suggest that bladder urothelial cells do more than provide a barrier function, but also may initiate bladder sensory signals. They can release putative neurotransmitters including ATP and nitric oxide in response to stretch or pharmacologic stimuli. They also express receptors typically found on neurons. Skin epithelial cells can function as sensors, and it may be that bladder urothelial cells function this way as well.
To better understand the potential for the bladder urothelial cell to participate in bladder sensory signaling, Yan Sun and colleagues from the University of Maryland designed single cell electrophysiological experiments in human normal and BPS/IC bladder urothelial cells. An inward rectifying potassium current was detected in all cells. A decreased conductance was detected in BPS/IC bladder urothelial cells. Conversely, increased potassium conductivity was induced in BPS/IC bladder urothelial cells by exposure to heparin binding epidermal growth factor-like growth factor (HB-EGF). The electrophysiological phenotype of normal and BPS/IC bladder urothelial cells was switched by exposing them to epidermal growth factor and genistein as well as HB-EGF.
The authors believe their findings suggest that potassium currents caused by alterations in growth factor levels could play a role in the pathophysiology of bladder urothelial cells in BPS/IC patients, yielding a potential future target for therapeutic intervention.
By Philip Hanno, MD, MPH
Am J Physiol Cell Physiol (July 12, 2006).
doi:10.1152/ajpcell.00209.2006
Link Here.
UroToday - the only urology website with original content written by global urology key opinion leaders actively engaged in clinical practice.
To access the latest urology news releases from UroToday, go to:
www.urotoday.com
Copyright © 2006 - UroToday
< back to top
- View the latest Urology / Nephrology News.
- Back to latest medical news headlines.
- Get medical news headlines weekly with our e-mail newsletter.
- Huge database of hospitals world wide .
Contact Our Medical News Editors
For any corrections of factual information, or to contact the editors please use our feedback form.
Please send any medical news or health news press releases to: pressrelease@medicalnewstoday.com
Back to top Back to front page List of All Medical Articles
Privacy Policy Disclaimer © 2006 MediLexicon International Ltd
Web design by Alastair Hazell from Bexhill, UK
News Categories
* Urology / Nephrology
* Abortion
* ADHD
* Aid / Disasters
* Alcohol / Addiction / Illegal Drugs
* Allergy
* Alzheimer's / Dementia
* Anxiety / Phobias
* Arthritis
* Autism
* Bio-terrorism / Terrorism
* Biology / Biochemistry
* Bipolar
* Bird Flu / Avian Flu
* Blood / Hematology
* Body Aches
* Bones / Orthopaedics
* Breast Cancer
* Cancer / Oncology
* Cardiovascular / Cardiology
* Caregivers / Homecare
* Cholesterol
* CJD / vCJD / Mad Cow Disease
* Cleft Palate
* Clinical Trials / Drug Trials
* Colorectal Cancer
* Complementary Medicine / Alternative Medicine
* Compliance
* Conferences
* Cosmetic Medicine / Plastic Surgery
* Crohn's
* Cystic Fibrosis
* Dentistry
* Depression
* Dermatology
* Diabetes
* Dyslexia
* Ear, Nose and Throat
* Endocrinology
* Epilepsy
* Erectile Dysfunction / Premature Ejaculation
* Eye Health / Optometry
* Fertility
* Flu / SARS
* GastroIntestinal / Gastroentorology
* Genetics
* Gout
* Headache / Migraine
* Health Insurance / Medical Insurance
* Hearing / Deafness
* HIV / AIDS
* Huntingtons Disease
* Hypertension
* Immune System / Vaccines
* Infectious Diseases / Bacteria / Viruses
* Irritable-Bowel Syndrome
* IT / Internet / E-mail
* Liver Disease / Hepatitis
* Lung Cancer
* Lupus
* Lymphoma / Leukemia
* Medical Devices
* Medical Malpractice / Litigation
* Medical Students
* Medicare / Medicaid / Tricare
* Men's health
* Mental Health
* MRI / PET / Ultrasound
* MRSA / Drug Resistance
* Multiple Sclerosis
* Muscular Dystrophy
* Neurology / Neuroscience
* Nursing
* Nutrition / Diet
* Obesity / Weight Loss / Fitness
* Pain / Anesthetics
* Parkinson's Disease
* Pediatrics
* Pharma Industry
* Pregnancy
* Primary Care / General Practice
* Prostate
* Psychology / Psychiatry
* Public Health
* Radiology / Nuclear Medicine
* Rehabilitation
* Respiratory / Asthma
* Schizophrenia
* Seniors / Aging
* Sexual Health / STDs
* Sleep / Sleep Disorders
* Smoking / Quit Smoking
* Sports Medicine / Fitness
* Statins
* Stem Cell Research
* Stroke / Neuroprotection
* Transplants / Organ Donations
* Tropical Diseases
* Urology / Nephrology
* Veterinary
* Water - Air Quality / Agriculture
* Women's Health / OBGYN
view all news categories
Navigation Links
Home
About Us
Advertising
News Archive Search
RSS/XML News Feeds
Free Website Feeds
Free Tools & Content
Your Opinions
Medical Jobs
Links
Contact Us
Health Professionals
Breast Cancer
Cardiovascular
GI
Prostate Cancer
Psychiatry
Respiratory
Stroke/Neuroprotection
Learning Resources
Urology
Patient Resources
Asthma
Blood Pressure
Breast Cancer (Patient)
Heartburn
Migraine
Tell a Friend
Your Name:
Your
E-mail:
Friend's
Name:
Friend's
E-mail:
full details.
Sign up to our weekly newsletter
MedReader RSS Reader
Clinical Trials
Medical Terms
Ad Banner - Prostate Line