glenda
02-23-2006, 09:57 AM
Quote from Aristo Vojdami, Ph.D., M.T;- "Although mycoplasmas are recognized primarily as extracellular parasites or pathogens of mucosal surfaces, recent evidence suggests that certain species may invade the host cells."
--suggesting its ability to cause infection.
Also his quote about MYCOPLASMA GENITALIUM; "This organism could be involved in pelvic inflmmatory disease."
--These statements were in an artical titled "Scientific Facts Versus Fiction About Mycoplasma"
Quoted out of an article by Ali Nawaz Kawaz Khan, MBBS, FRC..(about tuberculosis and the uro-genitourinary tract)- "Bladder tuberculosis infection is almost always secondary to renal involvement. Initially, interstitial cystitis occurs, eventually causing bladder mucosal ulceration and thickening of the bladder wall. End-stage disease causes scarring and bladder fibrosis, resulting in diminished capacity of the urinary bladder."
--NOTE, ACTIVE-tuberculosis which causes infection is difficult for MD's to determine. He also says, "Clinical features of female genital tuberculosis, if any, are nonspecific and diagnosis may be difficult." And, "In the US: The urogenital tract is the second most common site of tuberculosis after the lung."
Quotes out of an artical by - Christof von Eiff, Ralf Rene Reinert, Michel Dresken, Johannes Brauers, Deiter Hafner, and Georg Peters for the Multicenter Study on Antibiotic Resistance in Staphylococci and Other Gram-Positive Cocci Study (Mars) Group;
"Despite advances in antimicrobial therapy, the incidence of severe infections caused by multiple-drug-resistant bacteria has been increasing over the past 20 years."---"The worldwide emergence of multidrug-resistant gram-positive cocci such as MRSA, penicillin-resistant S. pneumoniae, and vancomycin-resistant enterococci as well as the corresponding increase in the number of enterococcal, streptococcal, and particularly staphylococcal infections in certain patients populations has limited clinicians' ability to use currently available antibiotics for therapy. Thus, new antimicrobial agents like quinupristin-dalfopristin are urgently needed."
Clinical investigation- Titled "Interstitial Cystitis: Can Chlamydia pneumoniae Be a Cause?"- Posted 6/16/2003- By- Gregory L. Alberts, MD, William M. Mitchell, MD, PhD, Charles W. Stratton, MD, Jenny J. Franke, MD;
"A possible causative organism of this inflammatory process is "Chlamydia pneumoniae, evidenced in this case report and ongoing studies."---"Franke and colleagues, have proposed a novel association between Chlamydia pneumoniae infecion and IC."---"As an obligte intracellular parasite, it replicates within eukaryotic cells, later releasing infectious, nonreplicating forms into the extracellular milieu. Macrophages do not eradicate this organism, and intracellular persistence may lead to disseminated infection. Organisms have been identified in endothelial and smooth muscle cells..."---"Studies have also explored a potential association between C pneumoniae and other inflammatory disorders..."---"Accurate laboratory diagnosis of C pneumoniae infection presents a difficult clinical challenge. Routine bacterial urine culture in patients with IC uniformly fails to isolate and identify this microorganism."
Case Report- Discussion;
"This case suggests a potential role for the intracellular organism C pneumoniae in the development of this chronic inflammatory process, as demonstrated by positive tissue culture from 2 separate sites. A recent article by Schilling and coworkers suggests a potential mechanism for intracellular persistence of typically noninvasive Escherichia coli. The intracellular location provides a safe haven from host defenses and antibiotic thirapies, while stimulating the production of inflammatory mediators. This persistence may be relevant in considering chronic diseases of the urinary tract, such as recurrent urinary tract infection and IC."---"Urine PCR analysis for the MOMP gene of C pneumoniae was positive in 81% of patients, compared with 27% of controls."
NGU- What is NGU?- Non-gonococcal urethritis (NGU) is an inflammation of the urethra that is not caused by gonorrhea.
What causes NGU?- The primary cause of NGU is a sexually transmitted infection called Chlamydia trachomatis. In approximately one-third of cases, the cause of the symptoms is not identified. In these cases bacteria called Ureaplasma urelyticum or Mycoplasma genitalium may be the cause. However, specific diagnostic tests are not abailable to identify these bacteria.
Quoted by Dr. Garth Nicolson in an interview regarding Chronic Fatigue Syndrome;
"We found that 50-60% of the patients that have these syndromes have infections, chronic infections that are the underlying cause of a lot of their morbidity or their illness and evidence for that is that we can find these micro-organisms deep inside the white blood cells in the blood and they're systemic. They go to all the tissues of the body and all the organs of the body and they cause all these complex signs and symptoms that occur all over the body..." (he's talking about mycoplasmas)--- "What we're finding is that we can't detect these highly pathogenic mycoplasma species in nornmal adults, so it's obviously much more prevalent in the patients with disease. We're looking at a number of other disorders, the most recent one we're looking at is Inflammatory Bowel Disorder and we're finding it there as well. It's very interesting, these different disorders, depending upon the organ system that's involved may involve a different species of mycoplasmas."--- (Dr. Garth Nicolson is the Chief Scientific Officer of the Institute for Molecular Medicine)
Quoted from artical; Why I Prescribe Antibiotics - By Gabe Mirkin M.D.;
"Before I prescribe any medication, I ask myself whether it will help or hurt. All of the autoimmune diseases cause severe disability. Conventional medications neither cure these diseases nor stop the progressive destruction that they cause."---"Accumulating data show that all of these conditions can be caused by infection. Many diseases that were thought to be autoimmune turn out to be infections."---"I know that most physicians who develop these conditions will treat themselves with antibiotics."---"Mycoplasma, chlamydia, and ureaplasma infections are extraordinarily difficult to diagnose and treat. No dependable tests are available to most practicing physicians that will rule infections with these bacteria in or out, and most doctors will not prescribe antibiotics to patients unless they have results of a laboratory test that confirms a specific infection."---"Once these infections are allowed to persist for months or years, they are extraordinarily difficult to cure and often require treatment for many months. Often patients do not take the medication long enough to be cured..."---"Sometimes, the germ has a surface protein that is similar to the surface protein in your cells. Then, not only do the antibodies attach to kill the germ, they also attach to and kill your own cells that have the same surface membranes."---(now talking about infertility)--"Many other studies show that the most common cause of infertility is a uterine infection."--"Infected people may have burning on urination, discomfort when the bladder is full, or an urgency to viod."--"Men and women can be infected with mycoplasma or ureaplasma, even though all available tests can't find them..."-----"If, as expected, no germ grows from the culture and your urine has a positive nitrite or leukocyte esterase test, the odds are overwhelming that you have a mycoplasma, chlamydia or ureaplasma infection and you and your partner should be treated."---"Prostate infections can be extraordinarily difficult to cure so you may have to be treated with injections of very high doses of antibiotics or with antibiotic pills for several months."
--suggesting its ability to cause infection.
Also his quote about MYCOPLASMA GENITALIUM; "This organism could be involved in pelvic inflmmatory disease."
--These statements were in an artical titled "Scientific Facts Versus Fiction About Mycoplasma"
Quoted out of an article by Ali Nawaz Kawaz Khan, MBBS, FRC..(about tuberculosis and the uro-genitourinary tract)- "Bladder tuberculosis infection is almost always secondary to renal involvement. Initially, interstitial cystitis occurs, eventually causing bladder mucosal ulceration and thickening of the bladder wall. End-stage disease causes scarring and bladder fibrosis, resulting in diminished capacity of the urinary bladder."
--NOTE, ACTIVE-tuberculosis which causes infection is difficult for MD's to determine. He also says, "Clinical features of female genital tuberculosis, if any, are nonspecific and diagnosis may be difficult." And, "In the US: The urogenital tract is the second most common site of tuberculosis after the lung."
Quotes out of an artical by - Christof von Eiff, Ralf Rene Reinert, Michel Dresken, Johannes Brauers, Deiter Hafner, and Georg Peters for the Multicenter Study on Antibiotic Resistance in Staphylococci and Other Gram-Positive Cocci Study (Mars) Group;
"Despite advances in antimicrobial therapy, the incidence of severe infections caused by multiple-drug-resistant bacteria has been increasing over the past 20 years."---"The worldwide emergence of multidrug-resistant gram-positive cocci such as MRSA, penicillin-resistant S. pneumoniae, and vancomycin-resistant enterococci as well as the corresponding increase in the number of enterococcal, streptococcal, and particularly staphylococcal infections in certain patients populations has limited clinicians' ability to use currently available antibiotics for therapy. Thus, new antimicrobial agents like quinupristin-dalfopristin are urgently needed."
Clinical investigation- Titled "Interstitial Cystitis: Can Chlamydia pneumoniae Be a Cause?"- Posted 6/16/2003- By- Gregory L. Alberts, MD, William M. Mitchell, MD, PhD, Charles W. Stratton, MD, Jenny J. Franke, MD;
"A possible causative organism of this inflammatory process is "Chlamydia pneumoniae, evidenced in this case report and ongoing studies."---"Franke and colleagues, have proposed a novel association between Chlamydia pneumoniae infecion and IC."---"As an obligte intracellular parasite, it replicates within eukaryotic cells, later releasing infectious, nonreplicating forms into the extracellular milieu. Macrophages do not eradicate this organism, and intracellular persistence may lead to disseminated infection. Organisms have been identified in endothelial and smooth muscle cells..."---"Studies have also explored a potential association between C pneumoniae and other inflammatory disorders..."---"Accurate laboratory diagnosis of C pneumoniae infection presents a difficult clinical challenge. Routine bacterial urine culture in patients with IC uniformly fails to isolate and identify this microorganism."
Case Report- Discussion;
"This case suggests a potential role for the intracellular organism C pneumoniae in the development of this chronic inflammatory process, as demonstrated by positive tissue culture from 2 separate sites. A recent article by Schilling and coworkers suggests a potential mechanism for intracellular persistence of typically noninvasive Escherichia coli. The intracellular location provides a safe haven from host defenses and antibiotic thirapies, while stimulating the production of inflammatory mediators. This persistence may be relevant in considering chronic diseases of the urinary tract, such as recurrent urinary tract infection and IC."---"Urine PCR analysis for the MOMP gene of C pneumoniae was positive in 81% of patients, compared with 27% of controls."
NGU- What is NGU?- Non-gonococcal urethritis (NGU) is an inflammation of the urethra that is not caused by gonorrhea.
What causes NGU?- The primary cause of NGU is a sexually transmitted infection called Chlamydia trachomatis. In approximately one-third of cases, the cause of the symptoms is not identified. In these cases bacteria called Ureaplasma urelyticum or Mycoplasma genitalium may be the cause. However, specific diagnostic tests are not abailable to identify these bacteria.
Quoted by Dr. Garth Nicolson in an interview regarding Chronic Fatigue Syndrome;
"We found that 50-60% of the patients that have these syndromes have infections, chronic infections that are the underlying cause of a lot of their morbidity or their illness and evidence for that is that we can find these micro-organisms deep inside the white blood cells in the blood and they're systemic. They go to all the tissues of the body and all the organs of the body and they cause all these complex signs and symptoms that occur all over the body..." (he's talking about mycoplasmas)--- "What we're finding is that we can't detect these highly pathogenic mycoplasma species in nornmal adults, so it's obviously much more prevalent in the patients with disease. We're looking at a number of other disorders, the most recent one we're looking at is Inflammatory Bowel Disorder and we're finding it there as well. It's very interesting, these different disorders, depending upon the organ system that's involved may involve a different species of mycoplasmas."--- (Dr. Garth Nicolson is the Chief Scientific Officer of the Institute for Molecular Medicine)
Quoted from artical; Why I Prescribe Antibiotics - By Gabe Mirkin M.D.;
"Before I prescribe any medication, I ask myself whether it will help or hurt. All of the autoimmune diseases cause severe disability. Conventional medications neither cure these diseases nor stop the progressive destruction that they cause."---"Accumulating data show that all of these conditions can be caused by infection. Many diseases that were thought to be autoimmune turn out to be infections."---"I know that most physicians who develop these conditions will treat themselves with antibiotics."---"Mycoplasma, chlamydia, and ureaplasma infections are extraordinarily difficult to diagnose and treat. No dependable tests are available to most practicing physicians that will rule infections with these bacteria in or out, and most doctors will not prescribe antibiotics to patients unless they have results of a laboratory test that confirms a specific infection."---"Once these infections are allowed to persist for months or years, they are extraordinarily difficult to cure and often require treatment for many months. Often patients do not take the medication long enough to be cured..."---"Sometimes, the germ has a surface protein that is similar to the surface protein in your cells. Then, not only do the antibodies attach to kill the germ, they also attach to and kill your own cells that have the same surface membranes."---(now talking about infertility)--"Many other studies show that the most common cause of infertility is a uterine infection."--"Infected people may have burning on urination, discomfort when the bladder is full, or an urgency to viod."--"Men and women can be infected with mycoplasma or ureaplasma, even though all available tests can't find them..."-----"If, as expected, no germ grows from the culture and your urine has a positive nitrite or leukocyte esterase test, the odds are overwhelming that you have a mycoplasma, chlamydia or ureaplasma infection and you and your partner should be treated."---"Prostate infections can be extraordinarily difficult to cure so you may have to be treated with injections of very high doses of antibiotics or with antibiotic pills for several months."