IC + steriods?

[linz]

Has anyone tried steriods for IC? A girl I know from the UK IC boards told me when she was diagnosed 9 years ago she was put on prednisolone for a few months and it zapped her bladder into being better. Since then she has two flare ups a year which only last a week or two, and are easily calmed down by anti inflammatries or a few days on the steriods again.

Can GP (general practitioner)prescribe steriods, or just urologist/specialists?

[tigger_gal]

I may be wrong but I thought steriods were not IC friendly... I would do some research and see what you can find out.. I haven't heard of any one taking them for IC pain.
hopefully some one will have the answers for you.

[Morgana]

PREDNISOLONE (www.bnf.org - I would sign up and visit for the full information, there is pages of it)

Indications: suppression of inflammatory and allergic disorders; inflammatory bowel disease, asthma, immunosuppression, rheumatic disease,

Cautions: adrenal suppression and infection, children and adolescents (growth retardation possibly irreversible), elderly (close supervision required particularly on long-term treatment); frequent monitoring required if history of tuberculosis (or X-ray changes), hypertension, recent myocardial infarction (rupture reported), congestive heart failure, liver failure, renal impairment, diabetes mellitus including family history, osteoporosis (post-menopausal women at special risk), glaucoma (including family history), corneal perforation, severe affective disorders (particularly if history of steroid-induced psychosis), epilepsy, peptic ulcer, hypothyroidism, history of steroid myopathy; pregnancy and breast-feeding

Contra-indications: systemic infection (unless specific antimicrobial therapy given); avoid live virus vaccines in those receiving immunosuppressive doses (serum antibody response diminished)

Side-effects: minimised by using lowest effective dose for minimum period possible;

gastro-intestinal effects include dyspepsia, peptic ulceration (with perforation), abdominal distension, acute pancreatitis, oesophageal ulceration and candidiasis; musculoskeletal effects include proximal myopathy, osteoporosis, vertebral and long bone fractures, avascular osteonecrosis, tendon rupture; endocrine effects include adrenal suppression, menstrual irregularities and amenorrhoea, Cushing's syndrome (with high doses, usually reversible on withdrawal), hirsutism, weight gain, negative nitrogen and calcium balance, increased appetite; increased susceptibility to and severity of infection; neuropsychiatric effects include euphoria, psychological dependence, depression, insomnia, increased intracranial pressure with papilloedema in children (usually after withdrawal), psychosis and aggravation of schizophrenia, aggravation of epilepsy; ophthalmic effects include glaucoma, papilloedema, posterior subcapsular cataracts, corneal or scleral thinning and exacerbation of ophthalmic viral or fungal disease; other side-effects include impaired healing, skin atrophy, bruising, striae, telangiectasia, acne, myocardial rupture following recent myocardial infarction, fluid and electrolyte disturbance, leucocytosis, hypersensitivity reactions (including anaphylaxis), thromboembolism, nausea, malaise, hiccups

Dose:
by mouth, initially, up to 10–20 mg daily (severe disease, up to 60 mg daily), preferably taken in the morning after breakfast; can often be reduced within a few days but may need to be continued for several weeks or months

Maintenance, usual range, 2.5–15 mg daily, but higher doses may be needed; cushingoid side-effects increasingly likely with doses above 7.5 mg daily

By intramuscular injection, prednisolone acetate, 25–100 mg once or twice weekly

[linz]

I may be wrong but I thought steriods were not IC friendly... I would do some research and see what you can find out.. I haven't heard of any one taking them for IC pain.
hopefully some one will have the answers for you.

but you get instills with steriods in...

thanks though, I'll have to ask my DR more about it.

[linz]

PREDNISOLONE (www.bnf.org - I would sign up and visit for the full information, there is pages of it)

Indications: suppression of inflammatory and allergic disorders; inflammatory bowel disease, asthma, immunosuppression, rheumatic disease,

Cautions: adrenal suppression and infection, children and adolescents (growth retardation possibly irreversible), elderly (close supervision required particularly on long-term treatment); frequent monitoring required if history of tuberculosis (or X-ray changes), hypertension, recent myocardial infarction (rupture reported), congestive heart failure, liver failure, renal impairment, diabetes mellitus including family history, osteoporosis (post-menopausal women at special risk), glaucoma (including family history), corneal perforation, severe affective disorders (particularly if history of steroid-induced psychosis), epilepsy, peptic ulcer, hypothyroidism, history of steroid myopathy; pregnancy and breast-feeding

Contra-indications: systemic infection (unless specific antimicrobial therapy given); avoid live virus vaccines in those receiving immunosuppressive doses (serum antibody response diminished)

Side-effects: minimised by using lowest effective dose for minimum period possible;

gastro-intestinal effects include dyspepsia, peptic ulceration (with perforation), abdominal distension, acute pancreatitis, oesophageal ulceration and candidiasis; musculoskeletal effects include proximal myopathy, osteoporosis, vertebral and long bone fractures, avascular osteonecrosis, tendon rupture; endocrine effects include adrenal suppression, menstrual irregularities and amenorrhoea, Cushing's syndrome (with high doses, usually reversible on withdrawal), hirsutism, weight gain, negative nitrogen and calcium balance, increased appetite; increased susceptibility to and severity of infection; neuropsychiatric effects include euphoria, psychological dependence, depression, insomnia, increased intracranial pressure with papilloedema in children (usually after withdrawal), psychosis and aggravation of schizophrenia, aggravation of epilepsy; ophthalmic effects include glaucoma, papilloedema, posterior subcapsular cataracts, corneal or scleral thinning and exacerbation of ophthalmic viral or fungal disease; other side-effects include impaired healing, skin atrophy, bruising, striae, telangiectasia, acne, myocardial rupture following recent myocardial infarction, fluid and electrolyte disturbance, leucocytosis, hypersensitivity reactions (including anaphylaxis), thromboembolism, nausea, malaise, hiccups

Dose:
by mouth, initially, up to 10–20 mg daily (severe disease, up to 60 mg daily), preferably taken in the morning after breakfast; can often be reduced within a few days but may need to be continued for several weeks or months

Maintenance, usual range, 2.5–15 mg daily, but higher doses may be needed; cushingoid side-effects increasingly likely with doses above 7.5 mg daily

By intramuscular injection, prednisolone acetate, 25–100 mg once or twice weekly


Hmm that's interesting, thank you for the link! I'm gonna ask my GP this week I think!

[Morgana]

Good luck, let us know what you find out...

Love

Mo
xxx

[ICNDonna]

I have had steroids instilled many times and it is always soothing. I also took steroids for a severe allergic reaction. It did help, but the side effects of swelling, etc., which can accompany steroid therapy was the bad thing and I was weaned off the steroids as soon as the allergic reaction was settled down.

Donna

[traceann]

Hello! I am currently on Prednisone for my colitis. I have no idea if it's helping my bladder or not, honestly as it was pretty calm before taking it. But I do know it hasn't made it worse or anything. But Donna is so right, I am getting tired of the side-effects puffiness, water-weight gain (to the point of one day can fit into jeans, next day can't, it's horrible) but I have another few weeks to go. Ugh. I have been on them since the middle of July, and we discovered I am one who has to wean off excruciatingly slowwwwww..... Started at 20mg...just now at 2.5......

But back to my point, it hasn't made bladder worse or anything!!!

Hugs!