Inaccurate statement by ICN??

[Esses]

The ICN homepage ("Dec 10, 2004 - IC News Alert- Botox found to be helpful in reducing the pain of IC")refers to a study supposedly reported in the Dec 2004 Journal of Urology wherein "Michael Chancellor and colleagues released the results of a study using botox...pain scores fell a whopping 79 per cent..."
I looked at the entire Dec 2004 edition of the Journal and obtained a copy of the only article re the use of Botox on IC patients (The Effect of Botulinum-A Toxin On Patients With Severe Urge Urinary Incontinence). It was based on a Duke Univ study, with no mention of Dr Chancellor. Moreover, there is not a single reference in the entire article to findings relative to "pain reduction"! The article speaks only to the use of Botox to treat incontinence.
Who wrote this abstract and where did the information come from??
Does anyone know anything about a study performed by Dr Chancellor using Botox??

[Betsie]

I would contact Jill for an answer to your question, she is quite thorough and I am sure will be happy to discuss this with you. Didn't see it, so can't comment.

[CinSin]

I didn't see the article but have had botox done five times and it has greatly reduced all my symptoms including and especially pain. I still have symptoms but nothing near like I had before. I just wish it worked for everybody like it has for me.

I do know that Michael Chancler has been studying botox for several years with the use of urgency and IC.

[vm]

Here is another article referencing the study reported on the ICN homepage. I don't know which Journal of Urology issue it was in, but this is the information discussed (Google is a beautiful thing):


Dec 10, 2004 — NEW YORK (Reuters Health) - Surprisingly, Botox injections seem to reduce pain caused by a condition called interstitial cystitis, results of a small study indicated.

Botulinum toxin A, commonly known as Botox, "may be a useful treatment option in patients with interstitial cystitis," which is characterized by urinary pain, frequency, and urgency, the researchers note in the medical journal Urology.

The finding is unexpected because Botox is thought to affect the types of nerves that control muscles, not those that transmit pain signals.

Dr. Michael B. Chancellor, from the University of Pittsburgh school of Medicine and colleagues treated 13 women with chronic interstitial cystitis. Six in the United States were injected with Botox and seven women in Poland were given another version of the drug, Dysport.

The medication was injected into 20 to 30 sites in the floor of the bladder while the women were under short general anesthesia or sedation.

Overall, nine of the 13 women saw improvement after treatment. Pain scores on a visual scale fell by 79 percent, and symptoms of daytime and nighttime urinary frequency fell by 44 percent and 45 percent, respectively.

Dr. Jeremy B. Tuttle, from the University of Virginia School of Medicine in Charlottesville, contends in an editorial that "if substantiated, these results imply our understanding of how botulinum toxin A operates and how interstitial cystitis symptoms arise may need revision."

Tuttle says Chancellor's team should be congratulated for their "surprising results and for devising a new promising treatment" for interstitial cystitis.

SOURCE: Urology, December 2004.

http://abcnews.go.com/Health/PainManagement/wireStory?id=319441

It says it's source is Urology, December 2004. Don't know if that is the same thing as Journal of Urology or not.


Here is a different article citing Cr. Chancellor and use of Botox:


Botox Treats Bladder Problems
MONDAY, May 10 (HealthDayNews) -- Some say botox will keep your face looking young, but evidence continues to grow that it will keep your bladder fit as well.

Botox injections have become a promising new treatment for a variety of lower urinary tract dysfunctions, according to a study presented May 9 at the annual meeting of the American Urological Association in San Francisco.

Dr. Michael Chancellor of the University of Pittsburgh School of Medicine has used botox since 1998 to treat 110 patients suffering a variety of bladder dysfunctions. The dysfunction cause all of them to experience incontinence, unable to hold their urine or completely empty their bladders.

About 67 percent of the patients reported a decrease or absence of incontinence after receiving the botox injections, Chancellor said. The decrease happened within seven days of treatment and lasted about six months.

Treatment involves injecting botox into the muscle that controls the bladder. The botox weakens the muscle and alleviates involuntary contractions, restoring normal bladder function.

--Dennis Thompson

SOURCES: University of Pittsburgh Medical Center, news release, May 9, 2004

http://www.medicinenet.com/script/main/art.asp?articlekey=32532

[Esses]

It MUST be a different publication. Thanks for the info!!

[icnmgrjill]

Thank you VM for citing those articles for me! I've been away two days... the first at a food conference (looking for more IC friendly foods) and today at a negotiation seminar. Back to work tomorrow!

Journal of Urology vs. Urology are indeed different journals.

Jill :)

[Esses]

Here is the info on the article

Botulinum toxin a has antinociceptive effects in treating interstitial cystitis
Urology, Volume 64, Issue 5, November 2004, Pages 871-875
Christopher P. Smith, Piotr Radziszewski, Andrzej Borkowski, George T. Somogyi, Timothy B. Boone and Michael B. Chancellor

[shennan]

to that urology article?

thx...

shenna

[Flore]

I have the complete article that Esses says, the problem is that I don´t how to publicate here

Is an incredible article, and in México we are giving to the Insurance companies for their knowledges

[Esses]

The article/study is too long to include in a post. Twice as many characters as the site can handle as a post. Any other suggestions as to how to get it to those interested??
As far as I know, its not available for free. I paid $30 to get access to the full text.

[Betsie]

If you recv'd it online could you cut/paste the link? Just a thought, I do that with some Jama archives...assuming subscription is current. ;)

[CinSin]

It was the feature (cover) article in the June 2004 publication of "The Journal of Urology". It was written by Christopher P Smith from the Scott Department of Urology at Baylor College of Medicine in Houston, Tx and Micheal B Chancler from the Department of Urology at the University of Pittsburg. Dr. Smith is my urologist, so I just asked him for a copy of the article right after it came out last summer. It is a really good article but lengthy. It is available online but does cost $30 to access it.

Cindy

[jaime15]

Someone correct me if I'm wrong here....but if people are having to pay for this article then it would be a copywrite infringement to copy or give out the article and the person who posted it would be heavily fined. Not to mention the possible repercussions of the site here.

[Betsie]

I think you are right actually...probably easier to copy the article and journal issue number...I would think most local libraries would possibly have it in periodicals...now that you mention it, my Jama articles did not open for others...its been awhile and my main computer is down, so I can't even look to see the subscription directives. Good point Jaime!

[Portia17]

I have a question after reading all this.

My urinating is actually not bad at all maybe - 8 or 9 times a day

I wanted to know if BOTOX works for BLADDER PAIN

Thanks